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1

Synthesis of Optically Active α-Aminoalkyl α‘-Halomethyl Ketone: A Cross-Claisen Condensation Approach

Honda, Yutaka, Katayama, Satoshi, Kojima, Mitsuhiko, Suzuki, Takayuki, Izawa, Kunisuke

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 41 KB

english, 2002

2

An efficient synthesis of γ-amino β-ketoester by cross-Claisen condensation with α-amino acid derivatives

Yutaka Honda, Satoshi Katayama, Mitsuhiko Kojima, Takayuki Suzuki, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 202 KB

english, 2003

3

ChemInform Abstract: An Economical Synthesis of Famciclovir

Toyota Hijiya, Keizo Yamashita, Mitsuhiko Kojima, Yumiko Uchida, Satoshi Katayama, Takayoshi Torii, Hiroshi Shiragami, Kunisuke Izawa

Journal:

Year:

1999

File:

PDF, 24 KB

1999

4

An Efficient Synthesis of γ-Amino β-Ketoester by Cross-Claisen Condensation with α-Amino Acid Derivatives.

Yutaka Honda, Satoshi Katayama, Mitsuhiko Kojima, Takayuki Suzuki, Kunisuke Izawa

Journal:

Year:

2003

File:

PDF, 137 KB

2003

5

Synthesis of 9-(2,3-Dideoxy-2-fluoro-β- d - t hreo -pentofuranosyl)adenine (FddA) via a Purine 3‘-Deoxynucleoside

Takamatsu, Satoshi, Maruyama, Tokumi, Katayama, Satoshi, Hirose, Naoko, Naito, Masaki, Izawa, Kunisuke

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

6

Pharmaceutical Process Chemistry (SHIOIRI:PROCESS CHEMISTRY O-BK) || From Milligrams to Tons: The Importance of Synthesis and Process Research in the Development of New Drugs

Shioiri, Takayuki, Izawa, Kunisuke, Konoike, Toshiro

Year:

2010

Language:

english

File:

PDF, 439 KB

english, 2010

7

Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

Zhu, Wei, Wang, Jiang, Wang, Shuni, Gu, Zhanni, Aceña, José Luis, Izawa, Kunisuke, Liu, Hong, Soloshonok, Vadim A.

Journal:

Journal of Fluorine Chemistry

Year:

2014

Language:

english

File:

PDF, 1.43 MB

english, 2014

8

Pharmaceutical Process Chemistry (SHIOIRI:PROCESS CHEMISTRY O-BK) || Asymmetric Oxidation with Hydrogen Peroxide, an Effective and Versatile Oxidant

Shioiri, Takayuki, Izawa, Kunisuke, Konoike, Toshiro

Year:

2010

Language:

english

File:

PDF, 229 KB

english, 2010

9

Pharmaceutical Process Chemistry (SHIOIRI:PROCESS CHEMISTRY O-BK) || Process Development of Amrubicin Hydrochloride, an Anthracycline Anticancer Drug

Shioiri, Takayuki, Izawa, Kunisuke, Konoike, Toshiro

Year:

2010

Language:

english

File:

PDF, 171 KB

english, 2010

10

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

Zhou, Yu, Wang, Jiang, Gu, Zhanni, Wang, Shuni, Zhu, Wei, Aceña, José Luis, Soloshonok, Vadim A., Izawa, Kunisuke, Liu, Hong

Journal:

Chemical Reviews

Year:

2016

Language:

english

File:

PDF, 15.90 MB

english, 2016

11

Comprehensive Natural Products II || Human–Environment Interactions – Taste

Izawa, Kunisuke

Year:

2010

Language:

english

File:

PDF, 738 KB

english, 2010

12

TailorâMade Amino Acids and Fluorinated Motifs as Prominent Traits in the Modern Pharmaceuticals

Mei, Haibo, Han, Jianlin, White, Sarah, Graham, Daniel J., Izawa, Kunisuke, Sato, Tatsunori, Fustero, Santos, Meanwell, Nicholas A., Soloshonok, Vadim Anatolievich

Journal:

Chemistry (Weinheim an der Bergstrasse, Germany)

Year:

2020

File:

PDF, 6.60 MB

2020

13

ChemInform Abstract: Introduction of a Benzoyl Group onto Riboside in Aqueous Solution: One-Step Synthesis of 6-Chloropurine 2′,3′-Di-O-benzoylriboside.

Shigetada Kozai, Satoshi Takamatsu, Kunisuke Izawa, Tokumi Maruyama

Journal:

Year:

1999

File:

PDF, 31 KB

1999

14

ChemInform Abstract: Synthesis of 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)adenine Bearing a Selectively Removable Protecting Group.

Tokumi Maruyama, Satoshi Takamatsu, Shigetada Kozai, Yoshiko Satoh, Kunisuke Izawa

Journal:

Year:

1999

File:

PDF, 35 KB

1999

15

ChemInform Abstract: Improved Synthesis of 9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA) Using Triethylamine Trihydrofluoride.

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Kunisuke Izawa

Journal:

Year:

2001

File:

PDF, 33 KB

2001

16

ChemInform Abstract: Practical Synthesis of 9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA) via a Purine 3′-Deoxynucleoside.

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Masaki Naito, Kunisuke Izawa

Journal:

Year:

2001

File:

PDF, 33 KB

2001

17

ChemInform Abstract: Dihalomethylation of N-Protected Phenylalanine Esters.

Tomoyuki Onishi, Yasuyuki Otake, Naoko Hirose, Takashi Nakano, Takayoshi Torii, Masakazu Nakazawa, Kunisuke Izawa

Journal:

Year:

2001

File:

PDF, 27 KB

2001

18

ChemInform Abstract: Practical Synthesis of α-Aminoalkyl-α′-chloromethylketone Derivatives. Part 1. Choromethylation of N-Protected 3-Oxazolidin-5-ones.

Tomoyuki Onishi, Naoko Hirose, Takashi Nakano, Masakazu Nakazawa, Kunisuke Izawa

Journal:

Year:

2001

File:

PDF, 31 KB

2001

19

ChemInform Abstract: Practical Synthesis of α-Aminoalkyl-α′-chloromethylketone Derivatives. Part 2. Chloromethylation of N-Imine-Protected Amino Acid Esters.

Tomoyuki Onishi, Takashi Nakano, Naoko Hirose, Masakazu Nakazawa, Kunisuke Izawa

Journal:

Year:

2001

File:

PDF, 31 KB

2001

20

ChemInform Abstract: Synthesis and in vitro Antiviral Activity Evaluation of 9-(2-Azido-2,3-dideoxy-β-D-threo-pentofuranosyl)adenine Derivatives

Satoshi Takamatsu, Kunisuke Izawa, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Erik De Clercq

Journal:

Year:

2001

File:

PDF, 28 KB

2001

21

ChemInform Abstract: Radical Deoxygenation and Dehalogenation of Nucleoside Derivatives with Hypophosphorous Acid and Dialkyl Phosphites.

Satoshi Takamatsu, Satoshi Katayama, Naoko Hirose, Masaki Naito, Kunisuke Izawa

Journal:

Year:

2002

File:

PDF, 28 KB

2002

22

ChemInform Abstract: Synthesis of Optically Active α-Aminoalkyl α′-Halomethyl Ketone: A Cross-Claisen Condensation Approach.

Yutaka Honda, Satoshi Katayama, Mitsuhiko Kojima, Takayuki Suzuki, Kunisuke Izawa

Journal:

Year:

2002

File:

PDF, 31 KB

2002

23

Practical Synthesis of Optically Active Styrene Oxides via Reductive Transformation of 2-Chloroacetophenones with Chiral Rhodium Catalysts.

Takayuki Hamada, Takayoshi Torii, Kunisuke Izawa, Ryoji Noyori, Takao Ikariya

Journal:

Year:

2003

File:

PDF, 152 KB

2003

24

Convenient Synthesis of Fluorinated Nucleosides with Perfluoroalkanesulfonyl Fluorides.

Satoshi Takamatsu, Satoshi Katayama, Naoko Hirose, Etienne De Cock, Geert Schelkens, Marc Demillequand, Jozef Brepoels, Kunisuke Izawa

Journal:

Year:

2003

Language:

english

File:

PDF, 218 KB

english, 2003

25

An Industrial Process for Synthesizing Lodenosine (FddA)

Kunisuke Izawa, Satoshi Takamatsu, Satoshi Katayama, Naoko Hirose, Shigetaka Kozai, Tokumi Maruyama

Journal:

Year:

2004

File:

PDF, 71 KB

2004

26

A Facile Synthetic Method for 3′-α-Fluoro-2′,3′-dideoxyadenosine

Satoshi Takamatsu, Satoshi Katayama, Masaki Naito, Keizo Yamashita, Takashi Ineyama, Kunisuke Izawa

Journal:

Year:

2004

File:

PDF, 55 KB

2004

27

A Practical Synthesis of Optically Active Aromatic Epoxides via Asymmetric Transfer Hydrogenation of α-Chlorinated Ketones with Chiral Rhodium-Diamine Catalyst.

Takayuki Hamada, Takayoshi Torii, Kunisuke Izawa, Takao Ikariya

Journal:

Year:

2004

Language:

english

File:

PDF, 47 KB

english, 2004

28

Asymmetric Transfer Hydrogenation of α-Aminoalkyl α′-Chloromethyl Ketones with Chiral Rh Complexes.

Takayuki Hamada, Takayoshi Torii, Tomoyuki Onishi, Kunisuke Izawa, Takao Ikariya

Journal:

Year:

2005

File:

PDF, 34 KB

2005

29

Development of an Industrial Process for Synthesizing Lodenosine (FddA)

Satoshi Takamatsu, Tokumi Maruyama, Kunisuke Izawa

Journal:

Year:

2006

File:

PDF, 8 KB

2006

30

ChemInform Abstract: Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]pyrimidine Ribonucleosides.

Piotr Januszczyk, Joanna Fogt, Jerzy Boryski, Kunisuke Izawa, Tomoyuki Onishi, Johan Neyts, Erik De Clercq

Journal:

Year:

2010

File:

PDF, 47 KB

2010

31

ChemInform Abstract: Synthesis of Optically Active α-Methyl Amino Acids Using Biotransformation as a Key Step

Masanobu Yatagai, Takayuki Hamada, Hiroyuki Nozaki, Shinji Kuroda, Kenzo Yokozeki, Kunisuke Izawa

Journal:

Year:

2010

File:

PDF, 12 KB

2010

32

ChemInform Abstract: Synthesis and Biological Activity of Fluorinated Nucleosides

Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa, Tomoyuki Onishi

Journal:

Year:

2010

File:

PDF, 15 KB

2010

33

Synthesis and resolution of 2,3-diamino-1-cyclohexanols

Kunisuke Izawa, Takashi Ineyama, Kazuaki Fujii, Tetsuo Suami

Journal:

Carbohydrate Research

Year:

1990

Language:

english

File:

PDF, 522 KB

english, 1990

34

Stereoselective synthesis of piperidine-2,6-dicarboxylic acids by photocatalytic reaction of aqueous cadmium(II) sulfide dispersion

Bunsho Ohtani, Satoshi Kusakabe, Katsumi Okada, Shigeto Tsuru, Kunisuke Izawa, Yusuke Amino, Sei-ichi Nishimoto

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 284 KB

english, 1995

35

Synthesis of N-acyl-α-amino esters via cobalt-catalyzed carbonylation of N-acyl-α-alkoxyamines

Kunisuke Izawa, Seiichi Nishi, Shoichi Asada

Journal:

Journal of Molecular Catalysis

Year:

1987

Language:

english

File:

PDF, 729 KB

english, 1987

36

A synthesis of 3′-α-fluoro-2′,3′-dideoxyadenosine via a bromine rearrangement during fluorination with MOST reagent

Satoshi Katayama, Satoshi Takamatsu, Masaki Naito, Shigehisa Tanji, Takashi Ineyama, Kunisuke Izawa

Journal:

Journal of Fluorine Chemistry

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

37

A practical synthesis of optically active aromatic epoxides via asymmetric transfer hydrogenation of α-chlorinated ketones with chiral rhodium–diamine catalyst

Takayuki Hamada, Takayoshi Torii, Kunisuke Izawa, Takao Ikariya

Journal:

Year:

2004

Language:

english

File:

PDF, 201 KB

english, 2004

38

Practical syntheses of penciclovir and famciclovir from N2-acetyl-7-benzylguanine

Takayoshi Torii, Hiroshi Shiragami, Keizo Yamashita, Yumiko Suzuki, Toyoto Hijiya, Tatsuki Kashiwagi, Kunisuke Izawa

Journal:

Year:

2006

Language:

english

File:

PDF, 353 KB

english, 2006

39

An efficient synthesis of N-protected threo (2R,3S)-3-amino-1,2-epoxy phenylbutane

Takayuki Suzuki, Yutaka Honda, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

40

A concise synthesis of 3′-α-fluoro-2′,3′-dideoxyguanosine (FddG) via 3′-α-selective fluorination of 8,2′-thioanhydronucleoside

Takayoshi Torii, Tomoyuki Onishi, Kunisuke Izawa, Tokumi Maruyama

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 110 KB

english, 2006

41

Chirospecific synthesis of (+)-PS-5 from L-glutamic acid

Tomihisa Ohta, Nobuaki Sato, Toshihiko Kimura, Shigeo Nozoe, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 229 KB

english, 1988

42

Practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA) via a purine 3′-deoxynucleoside

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Masaki Naito, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

43

Improved synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA) using triethylamine trihydrofluoride

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 78 KB

english, 2001

44

Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 1: Chloromethylation of N-protected 3-oxazolidin-5-ones

Tomoyuki Onishi, Naoko Hirose, Takashi Nakano, Masakazu Nakazawa, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 69 KB

english, 2001

45

Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 2: Chloromethylation of N-imine-protected amino acid esters

Tomoyuki Onishi, Takashi Nakano, Naoko Hirose, Masakazu Nakazawa, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 87 KB

english, 2001

46

Dihalomethylation of N-protected phenylalanine esters

Tomoyuki Onishi, Yasuyuki Otake, Naoko Hirose, Takashi Nakano, Takayoshi Torii, Masakazu Nakazawa, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 70 KB

english, 2001

47

Radical deoxygenation and dehalogenation of nucleoside derivatives with hypophosphorous acid and dialkyl phosphites

Satoshi Takamatsu, Satoshi Katayama, Naoko Hirose, Masaki Naito, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 69 KB

english, 2001

48

Introduction of a benzoyl group onto riboside in aqueous solution: One-step synthesis of 6-chloropurine 2′,3′-di-O-benzoylriboside

Shigetada Kozai, Satoshi Takamatsu, Kunisuke Izawa, Tokumi Maruyama

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 209 KB

english, 1999

49

Syntheses of 5-Amino-2-phenyl-4(3H)-pyrimidinone Derivatives Starting with Glycine

Takahashi, Daisuke, Izawa, Kunisuke, Honda, Yutaka

Journal:

Year:

2012

Language:

english

File:

PDF, 762 KB

english, 2012

50

New approaches to the industrial synthesis of HIV protease inhibitors

Honda, Yutaka, Katayama, Satoshi, Kojima, Mitsuhiko, Suzuki, Takayuki, Kishibata, Naomi, Izawa, Kunisuke

Journal:

Organic & Biomolecular Chemistry

Year:

2004

Language:

english

File:

PDF, 226 KB

english, 2004

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